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Phenotypic heterogeneity can be readily obtained by interlinking multiple gene regulatory pathways, effectively resulting in a genetic logic-AND gate. Although switching between states can occur within the cells' lifetime, cells can also pass their cellular state over to the next generation by a mechanism known as epigenetic inheritance and thus perpetuate the phenotypic state.
Importantly, heterogeneous populations can demonstrate increased fitness compared with homogeneous populations. This suggests that microbial cells employ bet-hedging strategies to maximize survival.
Here, we discuss the possible roles of interlinked bistable networks, epigenetic inheritance, and bet-hedging in bacteria. Stochastic switching as a survival strategy in fluctuating environments.
Senescence in a bacterium with asymmetric division. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Thinking about Bacillus subtilis as a multicellular organism. Rational design of memory in eukaryotic cells. Engineering yeast transcription machinery for improved ethanol tolerance and production. Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities.
Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Show 10 more references 10 of Smart citations by scite.
The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Explore citation contexts and check if this article has been supported or contradicted. Allele-specific single-cell RNA sequencing reveals different architectures of intrinsic and extrinsic gene expression noises. Cell Death in Evolutionary Transitions in Individuality.
Droplet Tn-Seq combines microfluidics with Tn-Seq for identifying complex single-cell phenotypes. Model genotype-phenotype mappings and the algorithmic structure of evolution. Trusting the hand that feeds: microbes evolve to anticipate a serial transfer protocol as individuals or collectives. Bistability in bacteria. Different genetic programmes within identical bacteria under identical conditions: the phenomenon of bistability greatly modifies our view on bacterial populations.
Bistability, epigenetics, and bet-hedging in bacteria.
Full text for this publication is not currently held within this repository. Alternative links are provided below where available. Clonal populations of microbial cells often show a high degree of phenotypic variability under homogeneous conditions. Stochastic fluctuations in the cellular components that determine cellular states can cause two distinct subpopulations, a property called bistability Phenotypic heterogeneity can be readily obtained by interlinking multiple gene regulatory pathways, effectively resulting in a genetic logic-ANTI gate.
Bistability, Epigenetics, and Bet-Hedging in Bacteria
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Kuipers Published Biology, Medicine Annual review of microbiology.