The six-level ARK Methotrexate Control and pooled human specimens containing methotrexate were used in the study. Each level was assayed in quadruplicate twice a day for 20 days. Each of the runs per day was separated by at least two hours. The within run, between day, total SD, and percent CVs were calculated. Mean result and SD were multiplied by the dilution factor.
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The ARK Methotrexate assay is the only liquid methotrexate assay on the market. It provides an assay range of 0. Guidelines for methotrexate therapy with leucovorin rescue usually recommend continuance of leucovorin until the methotrexate level falls below 0.
This is why low-level sensitivity is so important, especially for pediatric patients. Due to regulatory reasons, their future availability cannot be guaranteed. Please contact your local Siemens organization for further details. Methotrexate Assay. Methotrexate is an antineoplastic drug that is used in the treatment of specific cancers especially pediatric , psoriasis, rheumatoid arthritis, and other autoimmune conditions.
Methotrexate is extremely potent and has the potential to be very toxic. Thus, it prevents the growth of cells that grow rapidly, such as cancer, bone marrow, and skin cells. Methotrexate serum levels are dependent on many variables, including dose, mode of administration, individual metabolism, and individual pharmacokinetics. Leucovorin is usually administered intravenously as a rescue counteracting therapy.