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Craniopharyngioma is the most common pituitary tumor in childhood. It can compromise the pubertal development because of its evolution or treatment.

Syndrome of Klinefelter is the most common cause of hipergonadotrophic hypogonadism in males. We present the case of a year-old Belgian patient. He had a diagnosis of craniopharyngioma in childhood and he presented with panhypopituitarism after radiotherapy and surgical treatment.

At the age of 14, he started pubertal induction with gonadotropin therapy without clinical response. Failure of exogenous gonadotropin therapy revealed the hidden association of primary and secondary hypogonadism, demonstrating the importance of the followup and a multidisciplinary approach in these patients.

Keywords: Klinefelter syndrome; craniopharyngioma; hypogonadism; pituitary neoplasms; puberty. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract in English , Spanish. Similar articles A unique patient presenting with concomitant Klinefelter syndrome, Alport syndrome, and craniopharyngioma.

Rotondi M, et al. J Androl. Epub Apr PMID: Atypical presentation of a patient with both kallmann syndrome and a craniopharyngioma: case report and literature review. Jonklaas J. Endocr Pract. PMID: Review. Beisti Ortego A, et al. Arch Argent Pediatr. PMID: Spanish. Endoscope-assisted microsurgery for treatment of a suprasellar craniopharyngioma presenting precocious puberty.

Cheng WY, et al. Pediatr Neurosurg. The syndrome of inappropriate secretion of antidiuretic hormone: an unusual presentation for childhood craniopharyngioma: report of three cases. Gonzales-Portillo G, Tomita T. Gonzales-Portillo G, et al. Show more similar articles See all similar articles. Publication types Case Reports Actions. MeSH terms Adolescent Actions. Humans Actions.

Male Actions. Puberty Actions. Full-text links [x] Sociedad Argentina de Pediatria. Copy Download.


[Craniopharyngioma and Klinefelter Syndrome During the Pubertal Transition: A Diagnostic Challenge]

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