ELEVAGE CUNICOLE PDF

Toggle navigation. Have you forgotten your login? Poster communications. Hide details. Abstract : Reduce the use of antimicrobial compounds in livestock production is necessary to limit antimicrobial resistance development and to protect the health of animals, humans and ecosystems. This complex task may only be accomplished via the implementation of a systemic approach, which takes into account the management of animal health as a whole, avoiding simplistic strategies.

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Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. No residual test substance was observed after removal of the dressing. The skin irritation potential of 3-hydroxy-1,1-dimethylbutylperoxy-neodecanoate was assessed in a skin irritation test conducted according to the OECD guideline GLP study. A single dose of 0. The test substance was held in contact with the skin for 4 hours by means of a semi-occlusive dressing.

The cutaneous reactions were observed one hour, 24, 48 and 72 hours after removal of the dressing and then daily until day The mean score of the scores recorded after 24, 48 and 72 hours for each animal was calculated.

Having confirmed that the test substance had an irritant effect when administered by cutaneous route, the study began with one animal. Then, the results were confirmed with 2 additional animais. The eyes were not rinsed after instillation of the test substance. The ocular reactions were observed one hour, 24, 48 and 72 hours after the instillation. Slight score of 1 conjonctival chemosis, redness reactions were observed in all animals one hour after instillation.

No ocular reactions remained after 24, 48 and 72 hours. The skin irritation potential of 3-hydroxy-1,1-dimethylbutylperoxy-neodecanoate was assessed in an in vivo skin irritation test conducted according to the OECD guideline Clouzeau, Reversibility of the oedema was recorded on day 7 and erythema was no longer observed on day Between days 7 and 15, desquamation of the skin, signs of superficial reversible damages of the skin were observed in the 3 animals.

Therefore the substance is considered as irritant when administered by cutaneous route in rabbits. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. This information has not been reviewed or verified by the Agency or any other authority.

The content is subject to change without prior notice. Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner s of the respective information might violate the rights of the owner. REACH 3-hydroxy-1,1-dimethylbutyl 2-ethylmethylheptaneperoxoate. EC number: CAS number: Ecotoxicological Summary Aquatic toxicity Endpoint summary Short-term toxicity to fish Long-term toxicity to fish Short-term toxicity to aquatic invertebrates Long-term toxicity to aquatic invertebrates Toxicity to aquatic algae and cyanobacteria Toxicity to aquatic plants other than algae Toxicity to microorganisms Endocrine disrupter testing in aquatic vertebrates — in vivo Toxicity to other aquatic organisms Sediment toxicity Terrestrial toxicity Endpoint summary Toxicity to soil macroorganisms except arthropods Toxicity to terrestrial arthropods Toxicity to terrestrial plants Toxicity to soil microorganisms Toxicity to birds Toxicity to other above-ground organisms Biological effects monitoring Biotransformation and kinetics Additional ecotoxological information.

Administrative data Description of key information Key value for chemical safety assessment Additional information Justification for classification or non-classification. Administrative data Description of key information In an in vivo skin irritation test in rabbits OECD , GLP , 3-hydroxy-1,1-dimethylbutylperoxy-neodecanoate was irritating for skin Clouzeau, c. Reference Endpoint: skin irritation: in vivo Type of information: experimental study Adequacy of study: key study Reliability: 1 reliable without restriction Rationale for reliability incl.

Number of animals: 3 Details on study design: - Area of exposure: right flank, 6 cm2 - Total quantity applied: 0. Irritation parameter: erythema score Basis: animal: 1 and 2 Time point: other: 24, 48 and 72 hours Score: 3 Max. Reference Endpoint: eye irritation: in vivo Type of information: experimental study Adequacy of study: key study Study period: Reliability: 1 reliable without restriction Rationale for reliability incl. The lower and upper eyelids were held together for several seconds to avoid any loss of the test substance.

The right eye, which remained untreated, served as a control. If corneal opacification is difficult to determine, the eye can be examined under a U. Irritation parameter: cornea opacity score Basis: mean Time point: other: 24, 48 and 72 hours Score: 0 Max.

No occular reactions remained after 24, 48 and 72 hours. Interpretation of results: not irritating Remarks: Migrated information Criteria used for interpretation of results: OECD GHS Conclusions: Under the experimental conditions, the substance was not irritating to eyes in rabbits. The eye irritation potential of the substance was assessed in an in vivo test OECD Then, the results were confirmed with 2 additional animals.

Slight score of 1 conjunctival chemosis, redness reactions were observed in all animals one hour after instillation.

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Citation of this paper. A survey was conducted at farms counting a total of rabbits with breeding does. The results show that the average size of farms surveyed is breeding does per farm. The herd is composed of rabbit variable phenotype by different colors of the fur.

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