HIV: replication mechanism, pharmacological targets and inhibition by products derived from plants. The AIDS epidemy has spread out and led to the diversification on the research for new antiviral drugs. Natural products, especially those derived from plants, are well-recognized as excellent sources of new drugs. Several of them have inhibitory activity against HIV replication, and some have been already clinically tested, with favorable results. This review presents the biochemical basis of the viral cycle and the research up to date on the identification, determination of the mechanism of biological action together with the therapeutical potential of plants-derived natural products, in the inhibition of HIV. Keywords: HIV; natural products; antiviral.
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Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata were screened for in vitro antiviral activity against herpes simplex type I HSV-1 , vesicular stomatitis virus VSV and poliovirus type 1.
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Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Similar articles Virucidal activity presence in Trichilia glabra leaves. Cella M, et al. Rev Argent Microbiol. PMID: Antiviral screening of forty-two Egyptian medicinal plants.
Soltan MM, et al. J Ethnopharmacol. Epub Aug 8. Antiviral evaluation of plants from Brazilian Atlantic Tropical Forest. Extracts and molecules from medicinal plants against herpes simplex viruses. Khan MT, et al. Antiviral Res. PMID: Review. Akram M, et al. Phytother Res. Epub Jan Show more similar articles See all similar articles. Choi JG, et al. Front Pharmacol. In vivo anti-Trypanosoma cruzi activity of hydro-ethanolic extract and isolated active principles from Aristeguietia glutinosa and mechanism of action studies.
Varela J, et al. In vitro antiviral activity of plant extracts from Asteraceae medicinal plants. Visintini Jaime MF, et al. Virol J. Publication types Research Support, Non-U. Gov't Actions. Drug Evaluation, Preclinical Actions. Humans Actions. Plants, Medicinal Actions. South America Actions. Substances Antiviral Agents Actions.
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Brass et al. Afdhal, N. The natural history of hepatitis C, Seminars in Liver Disease, 24 2 , pp. Alcami, J. Ciclo replicative del VIH. Anderson, P. Ball, A.
Antiviral Activity of Some South American Medicinal Plants