FARMACOS CARDIOTONICOS PDF

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In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative 37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio , efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N -acylhydrazone NAH class, is also reported herein.

Asp-proteases Esquema 7 Os novos compostos sintetizados e. ODQ 42 O autor agradece ao Prof. Albuquerque, Dr. Sudo, Dra. Zapata-Sudo, Dr. Silva, Dra. Aracava, Dr. Castro, Dr. Melo e Dr. O autor agradece ao CNPq pela bolsa de produtividade e ao Pronex pelo apoio financeiro. Wermuth, C-G. Barreiro, E.

Black, J. Ganellin, C. Patani, G. Bradshaw, J. Gund, P. Arlington, S. Nova , 19 , ; ref. Para mais exemplos, veja: Barreiro, E. Nova , 25 , Murcko, M. Nova , 20 , Kubinyi, H. Ong, H. Setti, E. Murray, M.

Elion, G. Cushman, D. Ferreira, S. Nova , , 21 , McLeod, D. Shen, T. Lin, J. Leung, D. Tavel, J. Drugs , 9 , Perry, M. Denis, S. Soderling, S. Cell Biol. Montana, J. Hersperger, R. Dal Piaz, V. Burnouf, C. Lexchin, J. Fraga, C. Nova , 19 , Nova , 14 , Kagimoto, K. Manganiello, V. Heinisch, G. Wakisaka, C.

Janis, R. Ukena, D. Mathew, L. Lima, P. Santos, M. Jonas, R. Nova , 22 , Inter-alia : Palnitkar, S. Hoffman, E. Zhao, F. Inter-alia: Figueiredo, J. Acta Helv. Coelho, F. R; de Farias, F. Nova , 7 , Lima, M. Barreira, E.

Nova , 18 , Yamada, S. Albuquerque, E. Provisorial Number , Zucchi, R. Berchtold, M. Ruegg, U. Zapata-Sudo, G. Sudo, R. Gonzalez-Serratos, H.

Silva, C. Miranda, A. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

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In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative 37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio , efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N -acylhydrazone NAH class, is also reported herein. Asp-proteases Esquema 7 Os novos compostos sintetizados e.

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